UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer

Brittney S Harrington; Rahul Kamdar; Franklin Ning; Soumya Korrapati; Michael W Caminear; Lidia F Hernandez; Donna Butcher; Elijah F Edmondson; Nadia Traficante; Joy Hendley; Madeline Gough; Rebecca Rogers; Rohan Lourie; Jyoti Shetty; Bao Tran; Fathi Elloumi; Abdalla Abdelmaksoud; Madhu Lal Nag; Krystyna Mazan-Mamczarz; Carrie D House; John D Hooper; Christina M Annunziata

Journal article

UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer

Brittney S Harrington, Rahul Kamdar, Franklin Ning, Soumya Korrapati, Michael W Caminear, Lidia F Hernandez, Donna Butcher, Elijah F Edmondson, Nadia Traficante, Joy Hendley, Madeline Gough, Rebecca Rogers, Rohan Lourie, Jyoti Shetty, Bao Tran, Fathi Elloumi, Abdalla Abdelmaksoud, Madhu Lal Nag, Krystyna Mazan-Mamczarz, Carrie D House Show all

Journal of Experimental and Clinical Cancer Research | BMC | Published : 2023

DOI: 10.1186/s13046-023-02820-z

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Abstract

Background: Epithelial ovarian cancer (EOC) is a global health burden, with the poorest five-year survival rate of the gynecological malignancies due to diagnosis at advanced stage and high recurrence rate. Recurrence in EOC is driven by the survival of chemoresistant, stem-like tumor-initiating cells (TICs) that are supported by a complex extracellular matrix and immunosuppressive microenvironment. To target TICs to prevent recurrence, we identified genes critical for TIC viability from a whole genome siRNA screen. A top hit was the cancer-associated, proteoglycan subunit synthesis enzyme UDP-glucose dehydrogenase (UGDH). Methods: Immunohistochemistry was used to characterize UGDH expressio..

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University of Melbourne Researchers

Nadia Traficante Author

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Grants

Awarded by Intramural Research Program, Center for Cancer Research, National Cancer Institute

Awarded by National Cancer Institute, National Institutes of Health

Awarded by U.S. Army Medical Research and Materiel Command

Awarded by Cancer Foundation of Western Australia

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

Funding was provided by the Intramural Research Program, Center for Cancer Research, National Cancer Institute (ZIA BC011054, CMA). This project has been funded in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E and HHSN261201800001I. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. The Australian Ovarian Cancer Study Group was supported by the U.S. Army Medical Research and Materiel Command under DAMD17-01-1-0729, The Cancer Council Victoria, Queensland Cancer Fund, The Cancer Council New South Wales, The Cancer Council South Australia, The Cancer Council Tasmania and The Cancer Foundation of Western Australia (Multi-State Applications 191, 211 and 182) and the National Health and Medical Research Council of Australia (NHMRC; ID199600; ID400413 and ID400281).